logo
banner

Journals & Publications

Journals Publications Papers

Papers

Liver Protective and Reactive Oxygen Species Scavenging Effects of Emodin in Lipopolysaccharide/Bacillus Calmette Guerin-injured Mice by Optical Molecular Imaging
Mar 05, 2017Author:
PrintText Size A A

Title: Liver Protective and Reactive Oxygen Species Scavenging Effects of Emodin in Lipopolysaccharide/Bacillus Calmette Guerin-injured Mice by Optical Molecular Imaging
Authors: Li, N; Wang, JB; Zhao, YL; Zhang, L; Ma, XB; Li, XF; Song, J; Yang, X; Xiao, XH; Tian, J; Kang, TG
Author Full Names: Li, Na; Wang, Jia-Bo; Zhao, Yan-Ling; Zhang, Lin; Ma, Xi-Bo; Li, Xiao-Fei; Song, Jie; Yang, Xin; Xiao, Xiao-He; Tian, Jie; Kang, Ting-Guo
Source: INTERNATIONAL JOURNAL OF PHARMACOLOGY, 13 (2):175-182; 10.3923/ijp.2017.175.182 2017
Language: English
Abstract: Background: Hepatocytes damage is sometimes closely related to oxidative stress and reactive oxygen species which are the major contributors to lipopolysaccharide-induced liver injury. Emodin, the active natural product in rhubarb of hydroxyanthraquinone skeleton, has been reported of protective activity to liver tissue, whose mechanism is generally thought of antioxidation based on chemical reaction or indirect evidence. There is no visualized evidence proved the reactive oxygen species scavenging effect of emodin in vivo. Materials and Methods: The dynamic reactive oxygen species luminescent signal in mice injured by bacillus calmette guerin and lipopolysaccharide was monitored by using the optical molecular imaging approach. Results: The elevations of serum alanine aminotransferase and aspartate transaminase activities in bacillus calmette guerin/lipopolysaccharide-injured mice were reversed by emodin, indicating the protection of emodin to hepatocytes. And emodin significantly and dose-dependently attenuated the reactive oxygen species luminescent signal elicited by bacillus calmette guerin/lipopolysaccharide, indicating visually the in vivo reactive oxygen species scavenging effect of emodin. In addition, emodin significantly and dose-dependently elevated the activity of superoxide dismutase, content of reduced glutathione and total antioxidant capacity and meanwhile decreased the contents of hydrogen peroxide, lipid peroxides and malondialdehyde in livers of bacillus calmette guerin/lipopolysaccharide-injured mice. It could be attributed to the anti-oxidative effect of emodin which helps to maintain the reactive oxygen species balance in vivo. Conclusion: Emodin can protect liver against bacillus calmette guerin/lipopolysaccharide-induced injury and the mechanism includes reactive oxygen species scavenging effect and anti-lipid peroxidation at least.
ISSN: 1811-7775
eISSN: 1812-5700
IDS Number: EJ0EZ
Unique ID: WOS:000392882700007
*Click Here to View Full Record