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MRI/optical dual-modality imaging of vulnerable atherosclerotic plaque with an osteopontin-targeted probe based on Fe3O4 nanoparticles
Jan 06, 2017Author：
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Title: MRI/optical dual-modality imaging of vulnerable atherosclerotic plaque with an osteopontin-targeted probe based on Fe3O4 nanoparticles
Authors: Qiao, HY; Wang, YB; Zhang, RH; Gao, QS; Liang, X; Gao, L; Jiang, ZH; Qiao, RR; Han, D; Zhang, Y; Qiu, Y; Tian, J; Gao, MY; Cao, F
Author Full Names: Qiao, Hongyu; Wang, Yabin; Zhang, Ruohan; Gao, Quansheng; Liang, Xiao; Gao, Lei; Jiang, Zhenhua; Qiao, Ruirui; Han, Dong; Zhang, Yan; Qiu, Ya; Tian, Jie; Gao, Mingyuan; Cao, Feng
Source: BIOMATERIALS, 112 336-345; 10.1016/j.biomaterials.2016.10.011 JAN 2017
Language: English
Abstract: Rupture of vulnerable atherosclerotic plaque is the major pathological cause of luminal thrombosis in acute coronary syndromes. Since foamy macrophages have been identified as a prominent component in vulnerable atherosclerotic lesions and osteopontin (OPN) is reported to be highly expressed in foamy macrophages, OPN could be a potential target for vulnerable atherosclerotic plaque imaging. The current study designed an OPN-specific MRI/optical dual-modality probe to detect vulnerable plaques. Fluorescence imaging revealed that 24 h after injection of the Cy5.5-OPN-DMSA-MNPs (COD-MNPs), the atherosclerotic plaques in carotid artery exhibited significant higher signals in high fat diet (HFD) fed mice in comparison to the group injected with Cy5.5-IgG-DMSA-MNPs (CID-MNPs) or normal diet fed group injected with COD-MNPs (1.87 +/- 0.19 x 10(10) vs. 0.74 +/- 0.04 x 10(10), 0.73 +/- 0.03 x 10(10) p/sec/cm(2)/sr, P < 0.05). Meanwhile, MRI displayed stronger T-2 contrast enhancement 24 h post-injection at the area of atherosclerotic plaques in the carotid of HFD fed group injected with COD-MNPs than group injected with CID-MNPs or normal diet fed group injected with COD-MNPs (post/pre signal ratio: 0.64 +/- 0.04 vs. 0.95 +/- 0.02, 0.98 +/- 0.01, P < 0.05). As a dual-modality molecular probe, the resulting COD-MNPs conjugates exhibit promising potentials for noninvasive detection of vulnerable atherosclerotic plaque in vivo. (C) 2016 Elsevier Ltd. All rights reserved.
ISSN: 0142-9612
eISSN: 1878-5905
IDS Number: ED9CB
Unique ID: WOS:000389166700029
PubMed ID: 27788352