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Brain glucose metabolism is associated with hormone level in Cushing's disease: A voxel-based study using FDG-PET
Jan 06, 2017Author：
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Title: Brain glucose metabolism is associated with hormone level in Cushing's disease: A voxel-based study using FDG-PET
Authors: Liu, S; Wang, YY; Xu, KB; Ping, F; Wang, RZ; Li, F; Cheng, X
Author Full Names: Liu, Shuai; Wang, Yinyan; Xu, Kaibin; Ping, Fan; Wang, Renzhi; Li, Fang; Cheng, Xin
Source: NEUROIMAGE-CLINICAL, 12 415-419; 10.1016/j.nicl.2016.08.018 2016
Language: English
Abstract: Chronic exposure to elevated levels of glucocorticoids can exert a neurotoxic effect in patients, possibly manifesting as molecular imaging alterations in patients. The aim of this study was to investigate the potential association between brain metabolism and elevated hormone level using F-18-fluorodeoxyglucose positron emission tomography. We retrospectively enrolled 92 consecutive patients with confirmed diagnosis of Cushing's disease. A voxel-based analysis was performed to investigate the association between cerebral F-18-fluorodeoxyglucose uptake and serum cortisol level. Relatively impaired metabolism of specific brain regions correlated with serum-cortisol level was found. Specifically, notable correlations were found in the hippocampus, amygdala, and cerebellum, regions considered to be involved in the regulation and central action of glucocorticoids. Moreover, some hormone-associated regions were found in the frontal and occipital cortex, possibly mediating the cognitive changes seen in Cushing's disease. Our findings link patterns of perturbed brain metabolism relates to individual hormone level, thus presenting a substrate for cognitive disturbances seen in Cushing's disease patients, as well as in other conditions with abnormal cortisol levels. (C) 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license.
ISSN: 2213-1582
IDS Number: EF3AI
Unique ID: WOS:000390196400048
PubMed ID: 27622138