Title: Prefrontal Volume Mediates Effect of COMT Polymorphism on Interference Resolution Capacity in Healthy Male Adults
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| Authors: Xu, JY; Qin, W; Li, QJ; Li, W; Liu, F; Liu, B; Jiang, TZ; Yu, CS
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| Author Full Names: Xu, Jiayuan; Qin, Wen; Li, Qiaojun; Li, Wei; Liu, Feng; Liu, Bing; Jiang, Tianzi; Yu, Chunshui
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| Source: CEREBRAL CORTEX, 27 (11):5211-5221; 10.1093/cercor/bhw301 NOV 2017
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| Language: English
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| Abstract: There exist gender differences in the modulation of catechol-O-methyltransferase (COMT) Val158Met polymorphism on cognitive performance; however, the underlying gene-anatomy-cognition pathways remain unknown. Here we hypothesize that prefrontal volume may mediate the modulation of COMT Val158Met polymorphism on interference resolution capacity in a gender-dependent manner. In 261 healthy young human subjects (143 males and 118 females), a 2-way analysis of variance showed a COMT x gender interaction (P = 0.023) on interference resolution capacity. Val/Val subjects performed worse in Stroop interference test than Met/Met subjects only in males (P = 0.028). Voxel-wise analysis in the whole brain also exhibited a COMT x gender interaction on gray matter volume (GMV) in the left lateral frontal pole (FP). Val/Val male individuals exhibited significantly decreased GMV in the left lateral FP than Val/Met (P = 0.003) and Met/Met (P = 0.006) male carriers. Mediation analysis revealed that the GMV of the left lateral FP mediated the association between COMT polymorphism and interference resolution in males. These findings provide a gene-anatomy-cognition pathway to describe how COMT Val158Met polymorphism affects interference resolution capacity via modulating the prefrontal GMV in healthy male subjects.
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| ISSN: 1047-3211
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| eISSN: 1460-2199
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| IDS Number: FK0ZL
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| Unique ID: WOS:000413209200013
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| PubMed ID: 27664968
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