Title: Nuclear and Fluorescent Labeled PD-1-Liposome-DOX-Cu-64/IRDye800CW Allows Improved Breast Tumor Targeted Imaging and Therapy
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| Authors: Du, Y; Liang, XL; Li, Y; Sun, T; Jin, ZY; Xue, HD; Tian, J
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| Author Full Names: Du, Yang; Liang, Xiaolong; Li, Yuan; Sun, Ting; Jin, Zhengyu; Xue, Huadan; Tian, Jie
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| Source: MOLECULAR PHARMACEUTICS, 14 (11):3978-3986; 10.1021/acs.molpharmaceut.7b00649 NOV 2017
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| Language: English
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| Abstract: The overexpression of programmed cell death-1 (PD 1) in tumors as breast cancer makes it a possible target for cancer imaging and therapy. Advances in molecular imaging, including radionuclide imaging and near-infrared fluorescence (NIRF) imaging, enable the detection of tumors with high sensitivity. In this study, we aim to develop a novel PD-1 antibody targeted positron emission tomography (PET) and NIRF labeled liposome loaded with doxorubicin (DOX) and evaluate its application for in vivo cancer imaging and therapy. IRDye800CW and Cu-60 were conjugated to liposomes with PD-1 antibody labeling, and DOX was inside the liposomes to form theranostic nanopartides. The 4T1 tumors were successfully visualized with PD-1-LiposomeDOX-Cu-64/IRDye800CW using NIRF/PET imaging. The bioluminescent imaging (BLI) results showed that tumor growth was significantly inhibited in the PD-1-Liposome-DOX-treated group than the IgG control. Our results highlight the potential of using dual-labeled theranostic PD-1 mAb-targeted Liposome-DOX-Cu-64/IRDye800CW for the management of breast tumor.
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| ISSN: 1543-8384
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| IDS Number: FM2MX
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| Unique ID: WOS:000414820000034
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