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Alterations in Cortical Thickness in Nonmedicated Premature Ejaculation Patients: A Morphometric MRI Study
Mar 19, 2018Author:
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Title: Alterations in Cortical Thickness in Nonmedicated Premature Ejaculation Patients: A Morphometric MRI Study

 Authors: Guo, F; Xi, YB; Gao, M; Liu, L; Fei, NB; Qin, W; Li, C; Cui, LB; Yan, F; Yu, L; Yuan, JL; Yin, H

 Author Full Names: Guo, Fan; Xi, Yi-Bin; Gao, Ming; Liu, Lin; Fei, Ning-Bo; Qin, Wei; Li, Chen; Cui, Long-Biao; Yan, Fei; Yu, Lei; Yuan, Jian-Lin; Yin, Hong

 Source: JOURNAL OF MAGNETIC RESONANCE IMAGING, 47 (3):656-662; 10.1002/jmri.25808 MAR 2018

 Language: English

 Abstract: PurposePremature ejaculation (PE) is one of the most common sexual dysfunctions in men. However, there has been little research evaluating alterations in brain structure related to PE. We aimed to investigate the characteristics of nonmedicated PE patients in terms of brain morphometry. Materials and MethodsThe sample consisted with 32 medication-naive adult men with clinical diagnosed PE and matched 31 healthy controls. All participants received diagnostic interviews and 3.0 Tesla MRI scans. Automatic segmentation processing of MRI structure images was performed using FreeSurfer software and cerebral cortical thickness between groups was compared. ResultsThe PE group had thicker cortex in widespread regions, including the frontal, parietal and occipital lobe, and limbic system, compared with the healthy control group (P < 0.05). Moreover, the duration is negatively correlated with the mean cortical thickness of the right medial orbitofrontal cortex, right precentral gyrus and left superior frontal cortex (R-2 = 0.29, P < 0.003; R-2 = 0.163, P < 0.04; R-2 = 0.2, P < 0.02), while the Premature Ejaculation Diagnostic Tool score is negatively correlated with the mean cortical thickness of the left caudal middle frontal cortex (R-2 = 0.33, P < 0.005). ConclusionThe result highlights the structural features of PE and suggests the relationship with the severity of impairment is related to the severity of anatomic abnormality with the relevant brain region. These results support the value of imaging measures as markers for understanding the physiopathology of PE. Level of Evidence: 1 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2018;47:656-662.

 ISSN: 1053-1807

 eISSN: 1522-2586

 IDS Number: FW6RO

 Unique ID: WOS:000425446200008

 PubMed ID: 28736888

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