Title: Near Infrared-Emitting Persistent Luminescent Nanoparticles for Hepatocellular Carcinoma Imaging and Luminescence-Guided Surgery
Authors: Ai, T; Shang, WT; Yan, H; Zeng, CT; Wang, K; Gao, Y; Guan, TP; Fang, CH; Tian, J
Author Full Names: Ai, Ting; Shang, Wenting; Yan, Hao; Zeng, Chaoting; Wang, Kun; Gao, Yuan; Guan, Tianpei; Fang, Chihua; Tian, Jie
Source: BIOMATERIALS, 167 216-225; 10.1016/j.biomaterials.2018.01.031 JUN 2018
Language: English
Abstract: Hepatocellular carcinoma (HCC), the fifth most common cancer worldwide, is increasing nowadays and poses a serious threat to human health. However, if treated effectively and timely, it is clinically manageable or curable. Therefore, accurate detection and complete surgical resection remain priorities for HCC with a high potential of improving both survival and quality of life. Lacking of real-time guide technology, traditional surgery are usually relied on the subjective experience of surgeon, which have the limitation of high sensitivity detection tumor. Here, we developed a contrast agent, ZnGa2O4Cr0.004 (ZGC), used for guided surgery during operation to accurate delineation of HCC. ZGC showed excellent long-lasting afterglow properties that lasted for hours, which can aid in real-time guided surgery. Meanwhile, ZGC display high spatial resolution and deep penetration during pre-operation for diagnostic computed tomography (CT). Interestingly, we observed reverse imaging in the tumor region, known as a "dark hole", which further improves the contrast for surgery. This new multi-modality nanoparticle has great potential for accurate liver cancer imaging and resection guidance. (C) 2018 Published by Elsevier Ltd.
ISSN: 0142-9612
eISSN: 1878-5905
IDS Number: GE0JD
Unique ID: WOS:000430899200018
PubMed ID: 29573651