An Increased Breast Tumor-specific Imaging Method Applying to Intraoperative Image-guided Surgery
Abstract：Current medical imaging methods have played an important role in the preoperative diagnosis and postoperative evaluation. However, with the development of medical imaging technology, a higher standard for precision medicine is demanded for the treatment of clinical needs. How to detect small tumor lesions in early stage and how to determine the tumor tissue fast and with high specificity during surgery became challenging problems. The current imaging methods based on the anatomy and function faced the difficulty to cope with the new challenges in clinics. Fortunately, molecular imaging as a new medical imaging method shows great potential in this regard. However, the conventional molecular imaging method used tumor specific probes has the limitation of the non-specific uptake of the normal tissue, which limit its widespread application in clinical practice. Therefore, in order to improve the precision of breast tumor-specific imaging and accuracy of quantitative analysis in tumor target molecule, we propose an novel imaging method with high specificity based on our previous surgical navigation system. In order to realize breast cancer-specific imaging, we inject the tumor-specific and
Non-targeted agents together to achieve tumor correction in early stage breast cancer imaging. Our novel imaging method will assist surgeons precisely detect small breast tumor and resect specifically during operation. Our imaging method will provide an effective solution to the clinical needs in precise medicine.
Keywords: fluorescence molecular imaging; imaging method; image reconstruction; near infrared imaging
Contact:
CHI Chongwei
E-mail: chongwei.chi@ia.ac.cn
The State Key Laboratory of Management and Control for Complex Systems